I have 22x9.5's with 15mm offsets on my blazer. The fronts are 265/35 and the rears are 295/30's. I only took it for a ride around the block with these wheels on and 4/6 drop (4 right hand turns, 3 speed bumps and up/down a curb), but it didn't rub at all. I didn't have a c-notch in at the time, however, I didn't have any wheel tubs in the front either (don't own a set).
Here's what it looked like with the 4/6:
